Como were left to rue missed chances and a dramatic goal-line clearance, while Napoli also struck the woodwork in a tense 0-0 draw that saw managers Cesc Fàbregas and Antonio Conte share the points in a tightly contested Serie A encounter.
The clash, pitched as fifth against second, carried major implications in the race for Champions League qualification, with both sides aware that any slip could prove costly.
Como welcomed back several key players, with Nico Paz, Mergim Vojvoda and Sergi Roberto all passed fit despite recent knocks, though Jayden Addai remained unavailable.
Napoli, meanwhile, were boosted by the return of captain Giovanni Di Lorenzo to the bench after a long injury layoff, while Mathias Olivera, Juan Jesus, David Neres, Antonio Vergara and Romelu Lukaku all remained sidelined.
Como came closest to breaking the deadlock early on when Tasos Douvikas latched onto a Nico Paz pass, rounded Vanja Milinković-Savić, and looked destined to score—only for Amir Rrahmani to produce a crucial clearance off the line.
Martin Baturina then curled narrowly wide, while Milinković-Savić stood firm to deny Assane Diao in a one-on-one after a swift counter-attack.
Paz threatened from set pieces, sending a free-kick just over, before Jacobo Ramón somehow failed to connect from close range following a flicked corner.
After the interval, Rasmus Højlund had appeals waved away, while Diao again went close but could not direct his header on target.
Napoli responded with moments of danger of their own. Milinković-Savić reacted sharply to a deflected effort from Baturina, and Scott McTominay squandered a late chance, firing just wide with only the goalkeeper to beat.
The closest Napoli came was through Matteo Politano, who first made a vital defensive intervention inside his own box before launching a counter-attack.
His curling effort from distance then crashed against the far post, summing up a night of frustration for both sides.
In the end, despite the chances at both ends, neither team could find a breakthrough as the match finished goalless, leaving the top-five battle finely poised.